Honey
Honey, also known as yellow gold, is a highly addictive substance known for creating huge cravings. The ED of honey is about 0.1ng while the LD50 is disputed due to the widely varying ingredients but is generally accepted to be around 10-30g.
History[edit | edit source]
The history of honey starts with the history of bees who discovered honey while watching YouTube ads. They liked honey so much they decided to recreate it but instead of promo codes they got a highly addictive substance. This lead to them loosing most of their technology, focusing only on honey production. Annoyed by bees landing on their flowers eventually some humans decided to pay the bees a visit and to steel whatever they had. Thus introducing honey to humans. Due to higher brain capacity and already having a secure production method, humans didn't shift towards a society centered purely around honey, even though eventually they discovered they didn't even need bees to make honey out of flowers. This all happened before video, so there's a chance this was all just some cave man's invention justifying why bees rarely use youtube.
Physiological effects[edit | edit source]
Honey has very strong effects already at a low concentration. Due to its high concentration of sugar which is approximately 1.6mol/g the sweet receptors on the tongue activate. This is by first activating the sweet GPCR, a G-Protein receptor that activates through the binding of glucose or saccharose, the thus resulting loss of stability of the receptor then gives it a phosphorylating activity, transforming the G-Protein's GDP to GTP. This then leads to the Gα and Gβγ to stop being together. The Gβγ then activates the Phospholipase Cβ2 which in turn makes DAG and IP3 out of PIP2. The IP3 opens intracellular TRPM5-channels causing the Ca2+ in the cell to raise leading to a depolarization. This depolarization then causes more Ca2+ channels to open eventually leading to the release of neurotransmitters. As honey activates nearly all sweet receptors the nucleus accumbens starts going crazy leading to lots of happy feelings. Additionally once reaching the liver honey is metabolized into toxic compounds causing: hallucinations, food cravings, high risk behavior and lethargy
Intoxication[edit | edit source]
Due to the huge amounts of rewards honey releases in the brain the glutamate in the brain after using honey is extremely low, leading to the brain working much less. Honey reduces the base levels of glutamate, however it majorly increases the amount of glutamate released every time honey is used through neuroplasticity. This leads to honey consumers feeling less in general and start only feeling if they consumed honey. This can go to the point where there is no more glutamate unless honey is being consumed at which point even just a reduction in honey consumption can be deadly. Another way honey can be deadly is via diabetes. Due to spiking blood sugar more insulin is released. By repeatedly spiking insulin levels, the insulin receptors can be desensitized leading to diabetes mellitus type 2. The third and actually most common way to die of honey is having a bee allergy. Honey users often start craving more honey once they gave it a try. The bees then sting them all over, trying to protect their stash and some manage to sting the honey addict in their trachea, leading them to loose their ability to breathe unless someone gives them an epipen. The fourth common way to die of honey is actually drowning.
Known users[edit | edit source]
Winnie the Pooh[edit | edit source]
One of the most prolific honey users is disgraced child tv star Winnie the Pooh. During his early years he discovered honey at a party. At the start his consumption wasn't a problem and he became famous for being a wholesome actor for children, although insiders already warned that his honey addiction might become problematic eventually. Which of course eventually happened. While filming "The many adventures of Winnie the Pooh" his addiction got so bad, he had to be removed from set multiple times. Even with all the efforts of his friends and the production crew his addiction slightly managed to shine through at the movie.
Barry B. Benson[edit | edit source]
While seeming like an anti honey activist at first, Barry B. Benson is actually one of the most prolific users of honey in history. He did not sue the human race over honey in order to protect people, he sued in order to "bee" the only one with honey. His autobiography has multiple accounts of him bathing in honey and being only able to think about honey.
